BioRetroSynth: Biosynthesis of Novobiocin in E. coli

novobiocinNovobiocin, also known as albamycin or cathomycin, is an aminocoumarin antibiotic that is produced by the actinomycete Streptomyces niveus.

In the graph below, the different steps for producing novobiocin in E. coli by importing heterologous genes are shown. Enzymes in dotted circles correspond to putative reactions based on signatures predictions.

Click on enzymes and metabolites in the image in order to obtain more information about each step