BioRetroSynth: Biosynthesis of Clavulanic Acid in E. coli


Clavulanic acid is a beta-lactamase inhibitor combined with penicillin group antibiotics to overcome certain types of antibiotic resistance.

In the graph below, the different steps for producing clavulanic acid in E. coli by importing heterologous genes are shown. Enzymes in dotted circles correspond to putative reactions based on signatures predictions.

Click on enzymes and metabolites in the image in order to obtain more information about each step