Jean-Loup Faulon (invited speaker) – Retrosynthetic design of heterologous circuits for flexible therapeutic bioproduction

Evry, December 15, 2010

International Conference on Synthetic Biology

With the advent of high-throughput DNA sequencing and synthesis, it became possible to produce a list of molecular parts composing a living organism. Deconstruction of such parts can help us in the simplification of the existing organisms to be used later for grafting new functionalities. This Top-Down approach to Synthetic Biology has produced many results. Alternatively, the Bottom-Up approach consists of engineering context-independent biological parts that could be properly interfaced and standardized to generate a targeted behavior into an existing organism. An ultimate approach would consist in the de novo construction of organisms using such biological parts in an in vitro setting. The recent advances here are also very encouraging and they are allowing to better understand complex biochemical systems.