28 August 2023
Constraint-based metabolic models have been used for decades to predict the phenotype of microorganisms in different environments. However, quantitative predictions are limited
30 August 2022
We believe that the synthetic biology and metabolic engineering communities need to be provided with easily acessible and usable computational tools enabling them to apply
24 April 2020
Cell-free lysates are a major platform for in vitro protein production but batch-to-batch variation makes production difficult to predict. A research team from the Micalis
24 April 2020
Metabolic engineering aims to produce chemicals of interest from living organisms, to advance toward greener chemistry. Despite efforts, the research and development process
29 August 2019
While machine learning methods are used in many areas, including human health, interfacing these methods with the living world has been little explored at the molecular level.
19 August 2019
Synthetic biology is the field of engineering biology inspired by engineering in computation, standardization, and construction to develop new devices composed of biological
3 October 2018
RetroRules is a database of reaction rules for metabolic engineering (). Reaction rules are generic descriptions of chemical reactions that can be used in retrosynthesis workflows
25 September 2017
Synthetic biology applied to industrial biotechnology is transforming the way we produce chemicals. However, despite advances in the scale and scope of metabolic engineering,
13 April 2016
Genetically-encoded biosensors offer a wide range of opportunities to develop advanced synthetic biology applications. Circuits with the ability of detecting and quantifying
1 April 2016
Detection of chemical signals is critical for cells in nature as well as in synthetic biology, where they serve as inputs for designer circuits. Important progress has been
24 March 2016
Synthetic biology is today harnessing the design of novel and greener biosynthesis routes for the production of added-value chemicals and natural products. The design of novel
5 April 2013
We present an algorithm to compute molecular graph descriptors considering the stereochemistry of the molecular structure based on our previously introduced signature molecular
5 August 2011
Retrosynthetic map connecting reachable compounds to E. coli metabolism (blue)Synthetic biology is used to develop cell factories for production of chemicals by constructively
↬ Welcome
Our group is interested in synthetic biology in whole-cell and cell-free systems. We develop computational and wet lab protocols to search, design, and engineer biological pathways and networks. Other activities include retrosynthesis, structure-activity, sequence-function relationships, and the design of experiments using active and reinforcement machine learning methods. The applications of our work include synthetic metabolic pathways and genetic circuits engineering for bioproduction, biosensing, and biocomputing.
↬ Open Position(s)
- We have 1 Open Position: Seeking for a Research Associate Position in Data Science and Systems Biology Biology. Learn More.
- Interested in working with us? Don’t hesitate to contact us and share your CV!
